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Epigenome-wide studies of methylation in children support a role for epigenetic mechanisms in asthma; however, studies in adults are rare and few have examined non-atopic asthma. We conducted the largest epigenome-wide association study EWAS of blood DNA methylation in adults in relation to non-atopic and atopic asthma. Atopy was defined by serum specific immunoglobulin E IgE. Analyses were conducted using logistic regression. No associations were observed with atopy without asthma.
Implicated genes were enriched in pathways related to the nervous system or inflammation. We identified numerous, distinct differentially methylated CpG sites in non-atopic and atopic asthma. Many CpG sites from blood replicated in asthma-relevant tissues. These circulating biomarkers reflect risk and sequelae of disease, as well as implicate novel genes associated with non-atopic and atopic asthma. Abstract Epigenome-wide studies of methylation in children support a role for epigenetic mechanisms in asthma; however, studies in adults are rare and few have examined non-atopic asthma.
Publication types Research Support, N. Gov't, Non-P.